Description

2'-Fluoro-2'-Deoxy-Ara-A-3'-Phosphoramidite is a high-purity phosphoramidite monomer, a critical building block for the solid-phase synthesis of oligonucleotides. This compound is specifically engineered to introduce a 2'-fluoro modification on a 2'-deoxy-arabinose sugar backbone, conferring enhanced nuclease resistance and binding affinity to the resulting nucleic acid strands. It is an essential raw material for research and development in therapeutic oligonucleotides, including antisense drugs, siRNA, and aptamers, serving pharmaceutical, biotechnology, and diagnostic sectors globally.

Application

• Synthesis of Modified Antisense Oligonucleotides (ASOs): Used to incorporate 2'-fluoro-2'-deoxy-arabinonucleoside (FANA) modifications, enhancing target binding and metabolic stability.
• siRNA and miRNA Therapeutics: Key monomer for producing stabilized siRNA strands with improved pharmacokinetic profiles for gene silencing applications.
• Aptamer Development: Enables the creation of nuclease-resistant aptamers for diagnostic and therapeutic targeting.
• Research Grade Oligonucleotide Production: Employed in academic and industrial R&D for studying nucleic acid structure, function, and therapeutic potential.
• Diagnostic Probe Manufacture: Used to synthesize high-affinity, stable probes for molecular diagnostics and bio-sensing.
• Scale-up cGMP Manufacturing: Suitable for the production of active pharmaceutical ingredients (APIs) for clinical and commercial oligonucleotide-based drugs under controlled environments.

Basic Information

Product Name	2'-Fluoro-2'-Deoxy-Ara-A-3'-Phosphoramidite
CAS No.	329187-86-2
Molecular Formula	C34H43FN7O6P
Molecular Weight	695.72 g/mol
Synonyms	2'-F-Ara-A Phosphoramidite; 2'-Fluoro-2'-deoxyarabinoadenosine 3'-phosphoramidite; 9-[(2R,3S,4R,5R)-5-([Bis(1-methylethyl)amino](2-cyanoethoxy)phosphanyl]-3-fluoro-4-hydroxyoxolan-2-yl]-9H-purin-6-amine; FANA-A Phosphoramidite; 2'-F-2'-deoxy-β-D-arabinofuranosyladenine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-Fluoro-2'-deoxy-β-D-arabinoadenosine 3'-CE phosphoramidite; 2'-F-Ara-A-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2'-Deoxy-Ara-A-3'-Phosphoramidite is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (¹H NMR, ³¹P NMR, MS), to ensure it meets the stringent requirements for oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectra consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.