Description

N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-Benzyl-8-Bromo-N9-[3’,5’-o-(1,1,3,3-Tetrakis(Isopropyl)-1,3-Disiloxanediyl)--D-2’-Deoxyribofuranosyl]Guanine is a sophisticated, high-purity nucleoside analog derivative featuring a unique, multi-functional protective group architecture. This compound is a critical advanced intermediate in the synthesis of modified oligonucleotides and nucleotide-based therapeutics, where precise chemical modification is paramount. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel antiviral agents, antisense oligonucleotides, and other targeted molecular therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel guanosine-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in solid-phase and solution-phase synthesis to incorporate modified nucleosides into antisense oligonucleotides (ASOs) and siRNA strands, enhancing stability and target affinity.
• Prodrug Development: The protective groups (silyl, benzyl, disiloxanediyl) make this compound a precursor for controlled-release or tissue-targeted nucleotide prodrugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in nucleoside analog drug discovery programs.
• Bioconjugation: The reactive sites allow for further functionalization and conjugation to delivery vehicles like lipids or polymers.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex nucleoside active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	N2-(1,1,4,4-Tetramethyldisilylazacyclopentanyl)-O6-Benzyl-8-Bromo-N9-[3’,5’-o-(1,1,3,3-Tetrakis(Isopropyl)-1,3-Disiloxanediyl)--D-2’-Deoxyribofuranosyl]Guanine
CAS No.	328394-28-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-Bromo-N9-[(3',5'-di-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl)]-N2-(1,1,4,4-tetramethyl-1,4-disila-2-azacyclopentanyl)-O6-benzylguanine; 8-Br-Gua(silyl) derivative; Protected 8-Bromoguanosine intermediate; N2-(TMDSA)-O6-Bn-8-Br-N9-(TIPDS-dR)Guanine; 328394-28-1; Silyl-protected bromodeoxyguanosine analog
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Each batch undergoes comprehensive analytical characterization to ensure structural identity and chemical purity. We provide detailed Certificates of Analysis (COA) with data from HPLC (for assay and purity), NMR (1H, 13C for structural confirmation), and mass spectrometry. Quality is managed in compliance with ISO 9001 standards, and custom synthesis can be performed under GMP-like conditions for advanced preclinical and clinical stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.