Description

5-[3-[(Trifluoroacetyl)Amino]Propyl]Uridine is a high-purity, modified nucleoside building block of significant interest in advanced pharmaceutical and biochemical research. Its core value lies in its role as a key synthetic intermediate for the development of novel oligonucleotides and therapeutic agents, particularly in the fields of antisense technology and prodrug design. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require specialized nucleoside derivatives for cutting-edge applications.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for antisense and siRNA therapeutic applications.
• Biochemical Research: Serves as a valuable tool compound for studying enzyme mechanisms, nucleic acid metabolism, and cellular processes.
• Diagnostic Probe Development: Employed in the creation of labeled nucleotides for diagnostic assays and imaging techniques.
• Medicinal Chemistry: A key precursor for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in chemical biology and drug discovery.

Basic Information

Product Name	5-[3-[(Trifluoroacetyl)Amino]Propyl]Uridine
CAS No.	327623-80-3
Molecular Formula	C14H18F3N3O7
Molecular Weight	397.31 g/mol
Synonyms	5-[3-(Trifluoroacetamido)propyl]uridine; 5-(3-Trifluoroacetamidopropyl)uridine; N-[3-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propyl]-2,2,2-trifluoroacetamide; 5-(3-((2,2,2-Trifluoroacetyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione; Uridine, 5-[3-[(trifluoroacetyl)amino]propyl]-; Modified Nucleoside Intermediate; Trifluoroacetyl-protected Aminopropyl Uridine
EINECS	Contact for details

Quality Control

Our 5-[3-[(Trifluoroacetyl)Amino]Propyl]Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.