Description

Cyclopropanecarbonyl Chloride, 2-Nitro-, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring both a reactive acid chloride group and a nitro-substituted cyclopropane ring, enables the construction of complex, three-dimensional molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its defined stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides, where the cyclopropane moiety can impart specific biological activity and metabolic stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored properties, leveraging the strain and functionality of the cyclopropane ring.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, particularly in reactions involving strained ring systems and stereocontrolled bond formations.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-Nitro-, (1R,2R)-Rel- (9Ci)
CAS No.	326853-93-4
Molecular Formula	C4H4ClNO3
Molecular Weight	149.53 g/mol
Synonyms	(1R,2R)-2-Nitrocyclopropanecarbonyl chloride; rel-(1R,2R)-2-Nitrocyclopropanecarboxylic acid chloride; (1R,2R)-2-Nitrocyclopropanecarboxylic acid chloride; 2-Nitrocyclopropanecarbonyl chloride, (1R,2R)-rel-; (1R,2R)-rel-2-Nitrocyclopropanecarbonyl Chloride; (1R,2R)-2-Nitro-1-cyclopropanecarbonyl chloride; NSC 836902
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2-Nitro-, (1R,2R)-Rel- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical R&D and other advanced industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.