Description

3'-o-Dmt-T-Tna is a high-purity, protected nucleoside phosphoramidite monomer essential for oligonucleotide synthesis. This compound is a critical building block for the automated solid-phase synthesis of DNA and RNA sequences, enabling precise control over genetic material assembly. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in therapeutic oligonucleotide production, diagnostic probe development, and advanced genetic research.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Development: For the production of antisense oligonucleotides, siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probe Manufacturing: Used in creating labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Genetic Research & Genomics: Essential for constructing primers, gene fragments, and other synthetic nucleic acids in academic and industrial research.
• CRISPR/Cas9 Guide RNA Synthesis: A component in the synthesis of custom guide RNAs for genome editing technologies.
• Antisense Technology: Building block for molecules designed to modulate gene expression for research and therapeutic purposes.

Basic Information

Product Name	3'-o-Dmt-T-Tna
CAS No.	325683-89-4
Molecular Formula	C41H49N4O8P
Molecular Weight	756.83 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)thymidine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-Thymidine Phosphoramidite; Thymidine 5'-O-(4,4'-Dimethoxytrityl)-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dT Phosphoramidite; 2'-Deoxythymidine Phosphoramidite, DMT protected; T Phosphoramidite; 5'-DMT-dT-CE Phosphoramidite; N/A
EINECS	Contact for details

Quality Control

Our 3'-o-Dmt-T-Tna is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., argon or nitrogen) to maintain stability and reactivity. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.