Description

1-(α-L-Threofuranosyl)Thymine is a specialized nucleoside analog of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical building block and intermediate in the synthesis of novel therapeutic agents, particularly in the development of antiviral and anticancer nucleotide analogs. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, structurally defined molecules for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the production of novel antiviral and anticancer nucleotide-based drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related biological pathways.
• Antisense Oligonucleotide Synthesis: Serves as a modified nucleoside component for constructing oligonucleotides with enhanced stability or specific binding properties.
• Prodrug Development: Investigated for the design of prodrugs that improve the bioavailability and targeting of therapeutic nucleotides.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical analysis.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleotide analogs.

Basic Information

Product Name	1-(α-L-Threofuranosyl)Thymine
CAS No.	325683-84-9
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	L-Threofuranosylthymine; 1-[(2S,3S)-3,4-Dihydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; α-L-Threofuranosylthymine; Thymine L-threofuranoside; 1-(α-L-Threofuranosyl)thymine; L-TFT; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[(2S,3S)-tetrahydro-3,4-dihydroxy-2-furanyl]-
EINECS	Contact for details

Quality Control

Our 1-(α-L-Threofuranosyl)Thymine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.