Description

tert-Butyl 4-(Azidomethyl)Piperidine-1-Carboxylate (Saltdata: Free) is a versatile and high-purity Boc-protected piperidine derivative featuring a reactive azidomethyl functional group. This compound is a critical pharmaceutical intermediate and click chemistry building block, enabling efficient synthesis of complex molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for medicinal chemistry research and process development in the pharmaceutical, agrochemical, and advanced materials sectors, where reliable access to high-quality, well-characterized intermediates is paramount.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Click Chemistry Reagent: Enables efficient, modular bioconjugation and polymer functionalization via its reactive azide group, facilitating the creation of libraries for drug discovery and material science.
• Peptidomimetics & PROTACs: Used in the construction of peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its piperidine scaffold and orthogonal protecting group.
• Agrochemical Synthesis: Serves as a precursor in the development of novel crop protection agents and herbicides.
• Material Science: Employed in the synthesis of functional polymers, dendrimers, and surface coatings with tailored properties.
• Chemical Biology Probes: Utilized to create labeled probes for studying biological processes and target engagement.

Basic Information

Product Name	tert-Butyl 4-(Azidomethyl)Piperidine-1-Carboxylate (Saltdata: Free)
CAS No.	325290-50-4
Molecular Formula	C11H20N4O2
Molecular Weight	240.30 g/mol
Synonyms	1-Boc-4-(azidomethyl)piperidine; tert-Butyl 4-(azidomethyl)piperidine-1-carboxylate; 4-(Azidomethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(azidomethyl)piperidine; N-Boc-4-(azidomethyl)piperidine; Boc-4-(azidomethyl)piperidine; 325290-50-4; Piperidine-1-carboxylic acid, 4-(azidomethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Azidomethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with the standards required for GMP and ISO environments, supporting its use in critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.