Description

2-Chloro-5-Isothiocyanatopyridine is a versatile and highly reactive heterocyclic building block, primarily valued for its dual functional groups that enable selective derivatization. This compound is essential for the synthesis of complex molecules, particularly in the development of advanced pharmaceuticals and agrochemicals. It is a critical intermediate for researchers and manufacturers in medicinal chemistry, crop protection, and material science who require precise and reliable chemical scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the reactivity of the isothiocyanate group.
• Ligand and Chelator Development: Serves as a precursor for creating specialized ligands used in catalysis and metal complexation studies.
• Bioconjugation and Probe Synthesis: The isothiocyanate group readily reacts with amines, making it useful for labeling proteins, antibodies, and other biomolecules.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored properties.
• Custom Synthesis and R&D: A valuable starting material for contract research organizations (CROs) and fine chemical companies performing bespoke synthesis.

Basic Information

Product Name	2-Chloro-5-Isothiocyanatopyridine
CAS No.	323588-81-4
Molecular Formula	C6H3ClN2S
Molecular Weight	170.62 g/mol
Synonyms	5-Isothiocyanato-2-chloropyridine; 2-Chloro-5-pyridyl isothiocyanate; 2-Chloropyridine-5-isothiocyanate; 2-Chloro-5-isothiocyanato-pyridine; Pyridine, 2-chloro-5-isothiocyanato-; 2-Chloro-5-thiocyanatopyridine (common misnomer); 2-Cl-5-NCS-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Isothiocyanatopyridine is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and IR spectroscopy, to ensure compliance with industry standards and precise customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.