Description

Axitinib CAS NO 319460-85-0 is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs). This compound is critical for targeted cancer therapy, specifically designed to inhibit tumor angiogenesis and progression. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in oncology drug development and clinical studies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in formulated anti-cancer medications.
• Oncology Research: A key reference standard and tool compound for studying VEGFR signaling pathways and angiogenesis in preclinical models.
• Drug Development: Used in the synthesis and development of new targeted therapies for renal cell carcinoma and other solid tumors.
• Biochemical Assays: Employed in high-throughput screening and enzymatic assays to evaluate kinase inhibition.
• Clinical Trial Materials: Sourced for the production of clinical supplies under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in university and institutional labs for molecular biology and pharmacology studies.

Basic Information

Product Name	Axitinib
CAS No.	319460-85-0
Molecular Formula	C22H18N4OS
Molecular Weight	386.47 g/mol
Synonyms	AG-013736; Inlyta; N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide; Axitinib (AG-013736); AG 013736; AG013736; BMS-908662
EINECS	Contact for details

Quality Control

Our Axitinib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency. We provide comprehensive quality documentation, including Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (IR, NMR), and impurity profiles. The product meets stringent specifications suitable for research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.