Description

1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4S)- (9Ci) is a high-value, chiral sulfite derivative primarily used as a key synthetic intermediate in advanced organic synthesis. Its significance lies in its role as a versatile building block for introducing protected sulfite or sulfate functionalities in a stereocontrolled manner, enabling the development of complex molecules with high purity. This compound is essential for research and production in the pharmaceutical industry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs), prodrugs, and specialty fine chemicals where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and prodrugs, especially in antiviral and anticancer research.
• Asymmetric Synthesis: Used as a reagent in stereoselective reactions to construct complex molecular architectures with defined chirality.
• Sulfation/Phosphorylation Agent: Acts as a protected sulfite donor in the synthesis of sulfate esters and related compounds found in bioactive molecules.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, ligands, and catalysts for research and industrial processes.
• Process Chemistry & Scale-up: Serves as a key intermediate in the development and optimization of scalable synthetic routes for target molecules.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4S)- (9Ci)
CAS No.	316373-91-8
Molecular Formula	C5H7ClO4S
Molecular Weight	198.62 g/mol
Synonyms	(4S)-4-Methyl-1,3,2-dioxathiolane-4-carbonyl chloride 2-oxide; (4S)-4-Methyl-2-oxo-1,3,2-dioxathiolane-4-carbonyl chloride; (S)-4-Methyl-1,3,2-dioxathiolane-4-carbonyl chloride 2-oxide; (S)-4-Methyl-2-oxo-1,3,2-dioxathiolane-4-carbonyl chloride; Chiral methyl dioxathiolane carbonyl chloride oxide; (S)-configured dioxathiolane sulfite chloride; (4S)-4-Methyl-1,3,2-dioxathiolane-4-carboxylic acid chloride 2-oxide
EINECS	Contact for details

Quality Control

Our production of 1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and precise assay determination. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.