Description

1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4R)- (9Ci) is a high-purity, chiral sulfite derivative and a key reactive intermediate in advanced organic synthesis. Its primary value lies in its role as a versatile building block for introducing chiral, sulfur-containing motifs into complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of new drug candidates, especially in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific chirality enhances biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Employed to introduce functional sulfite or sulfate groups into polymer backbones for specialty materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and reaction pathways involving sulfur(VI) chemistry.
• Fine Chemical Production: Integral to the multistep synthesis of complex, high-value fine chemicals and flavors & fragrances.

Basic Information

Item	Details
Product Name	1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4R)- (9Ci)
CAS No.	316373-90-7
Molecular Formula	C5H7ClO4S
Molecular Weight	198.62 g/mol
Synonyms	(4R)-4-Methyl-1,3,2-dioxathiolane-4-carbonyl chloride 2-oxide; (R)-4-Methyl-1,3,2-dioxathiolane-4-carbonyl chloride 2-oxide; (R)-4-Methyl-2-oxo-1,3,2-dioxathiolane-4-carbonyl chloride; Methyl Dioxathiolane Carbonyl Chloride Oxide; Chiral Sulfite Ester Acid Chloride; (R)-configuration isomer of CAS 316373-90-7. Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of 1,3,2-Dioxathiolane-4-Carbonyl Chloride, 4-Methyl-, 2-Oxide, (4R)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and IR spectroscopy to confirm identity, enantiomeric excess, and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.