Description

6-Morpholinonicotinoyl Chloride is a versatile and reactive chemical building block, specifically an acid chloride derivative of a nicotinic acid analog. Its primary value lies in its role as a key intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the morpholine and pyridine motifs are common.
• Chemical Research & Development: Serves as a versatile reagent for introducing the 6-morpholinonicotinoyl moiety into target molecules via amide bond formation or other nucleophilic substitutions.
• Material Science: Potential use in the synthesis of specialty polymers, ligands for catalysis, or organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	6-Morpholinonicotinoyl Chloride
CAS No.	313350-36-6
Molecular Formula	C10H11ClN2O2
Molecular Weight	226.66 g/mol
Synonyms	6-Morpholinopyridine-3-carbonyl chloride; 3-Pyridinecarbonyl chloride, 6-morpholino-; 6-Morpholinonicotinic acid chloride; 6-Morpholinonicotinyl chloride; 2-Morpholin-4-ylpyridine-5-carbonyl chloride; Nicotinoyl chloride, 6-morpholino-
EINECS	Contact for details

Quality Control

Our 6-Morpholinonicotinoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.