Description

2'-Deoxyguanosine Monohydrate is a high-purity nucleoside building block essential for life science research and pharmaceutical development. This compound serves as a critical precursor in the synthesis of oligonucleotides, DNA probes, and various antiviral and anticancer nucleotide analogs. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors. Consistent quality and reliable supply are paramount for applications in sensitive molecular biology and therapeutic agent synthesis.

Application

• Oligonucleotide Synthesis: A fundamental phosphoramidite monomer for solid-phase synthesis of DNA strands and probes.
• Pharmaceutical Intermediates: Key starting material in the production of nucleoside-based antiviral drugs (e.g., for HIV, hepatitis) and anticancer agents.
• Biochemical Research: Used in enzymatic studies, as a substrate for DNA polymerases, and in metabolic pathway analysis.
• Diagnostic Reagents: Component in the manufacture of labeled nucleotides for sequencing, PCR, and microarray technologies.
• Cell Culture & Media: Supplement for specialized cell culture media requiring specific nucleosides.
• Standards & References: Serves as an analytical standard for quality control and purity assessment in related products.

Basic Information

Product Name	2'-Deoxyguanosine Monohydrate
CAS No.	312693-72-4
Molecular Formula	C10H13N5O4 • H2O
Molecular Weight	285.25 g/mol (Anhydrous: 267.24 g/mol)
Synonyms	2'-Deoxyguanosine hydrate; Deoxyguanosine monohydrate; dG Monohydrate; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one monohydrate; 2'-Deoxy-Guanosine Monohydrate; Guanine deoxyriboside monohydrate; dGuo • H2O
EINECS	Contact for details

Quality Control

Our 2'-Deoxyguanosine Monohydrate is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for research and GMP-grade manufacturing. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	5.0% - 8.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solvent Residues (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.