Description

2'-F-N2-Ibu-2'-Ara-Dg CAS NO 308356-20-9 is a specialized nucleoside analog derivative, a key building block in advanced pharmaceutical research and development. Its primary value lies in its role as a modified precursor for the synthesis of novel antiviral and anticancer therapeutic agents, enabling targeted drug design. This high-purity intermediate is essential for research institutions and pharmaceutical companies focused on developing next-generation nucleotide-based therapies, particularly in the fields of virology and oncology.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of modified nucleoside-based Active Pharmaceutical Ingredients (APIs).
• Antiviral Drug Research: Used in the development of novel antiviral compounds targeting specific viral polymerases.
• Oncology Therapeutics: Serves as a building block for prodrugs and targeted cancer treatments that interfere with DNA/RNA synthesis in malignant cells.
• Biochemical Research: Utilized in mechanistic studies and as a probe to understand nucleic acid interactions and enzyme inhibition.
• Prodrug Development: Key component in creating masked nucleotide analogs designed for improved bioavailability and targeted delivery.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific drug discovery projects.

Basic Information

Product Name	2'-F-N2-Ibu-2'-Ara-Dg
CAS No.	308356-20-9
Molecular Formula	C₁₉H₂₄FN₅O₆
Molecular Weight	437.42 g/mol
Synonyms	2'-Fluoro-N2-isobutyryl-2'-arabino-deoxyguanosine; 2'-F-N2-Ibu-dG; 2'-Fluoro-2'-deoxyarabino-guanosine N2-isobutyrate; 9-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(2-methylpropanoylamino)-1H-purin-6-one; 2'-F-ara-dG N2-Ibu; 2'-Fluoro-N2-isobutyryl-guanosine arabino isomer; 308356-20-9; N2-Ibu-2'-F-2'-ara-Guanosine
EINECS	Contact for details

Quality Control

Every batch of 2'-F-N2-Ibu-2'-Ara-Dg is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.