Description

2-(Trifluoromethyl)Pyrimidine-5-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its pyrimidine core and trifluoromethyl and acid chloride functional groups. This compound matters for its critical role in facilitating efficient carbon-carbon and carbon-heteroatom bond formation, enabling the synthesis of complex molecules with enhanced properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients, particularly where the introduction of a trifluoromethylated heterocyclic scaffold is desired.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the pyrimidine moiety and fluorine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials requiring specific heterocyclic architectures.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based probes (ABPs), and affinity tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(Trifluoromethyl)Pyrimidine-5-Carbonyl Chloride
CAS No.	306960-78-1
Molecular Formula	C6H2ClF3N2O
Molecular Weight	210.54 g/mol
Synonyms	5-(Chlorocarbonyl)-2-(trifluoromethyl)pyrimidine; Pyrimidine-5-carbonyl chloride, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid chloride; 2-Trifluoromethylpyrimidine-5-carbonyl chloride; 2-(Trifluoromethyl)-5-pyrimidinecarbonyl chloride; 5-Carboxy-2-trifluoromethylpyrimidine chloride
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Pyrimidine-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water, alcohols, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.