Description

2-(2,3-Dihydro-1-Benzofuran-5-Yl)Thiazole-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate featuring a fused benzofuran-thiazole core activated by an acid chloride group. This compound matters for its role as a critical building block in the synthesis of complex heterocyclic molecules, enabling the introduction of the 2-(2,3-dihydrobenzofuran-5-yl)thiazole moiety into target structures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the benzofuran-thiazole scaffold for bioactivity.
• Material Science: Serves as a precursor for functionalized polymers or organic electronic materials due to its conjugated system.
• Chemical Biology: Employed in the creation of molecular probes and activity-based protein profiling (ABPP) reagents where the reactive acyl chloride allows for covalent linkage.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes requiring this specialized intermediate.

Basic Information

Product Name	2-(2,3-Dihydro-1-Benzofuran-5-Yl)Thiazole-4-Carbonyl Chloride
CAS No.	306936-10-7
Molecular Formula	C12H8ClNO2S
Molecular Weight	265.71 g/mol
Synonyms	5-(4-Chlorocarbonylthiazol-2-yl)-2,3-dihydrobenzofuran; 2-(2,3-Dihydrobenzofuran-5-yl)-1,3-thiazole-4-carbonyl chloride; 2-(2,3-Dihydro-1-benzofuran-5-yl)-4-thiazolecarbonyl chloride; Thiazole-4-carbonyl chloride, 2-(2,3-dihydro-5-benzofuranyl)-; 306936-10-7; 2-(2,3-Dihydrobenzofuran-5-yl)thiazole-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-(2,3-Dihydro-1-Benzofuran-5-Yl)Thiazole-4-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request for quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.