Description

Sagopilone CAS NO 305841-29-6 is a synthetic epothilone analog, representing a significant class of microtubule-stabilizing agents. This compound is of paramount importance in advanced pharmaceutical research and development due to its potent antitumor activity. It is primarily required by research institutions and pharmaceutical companies engaged in oncology drug discovery, preclinical studies, and the development of novel chemotherapeutic agents.

Application

• Oncology Research: As a key investigational compound for studying microtubule dynamics and cancer cell apoptosis mechanisms.
• Drug Discovery: Serving as a lead compound or reference standard in the development of next-generation chemotherapeutic agents.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles.
• Biochemical Assays: Used as a tool compound to investigate signal transduction pathways and resistance mechanisms in cancer cells.
• Pharmaceutical Reference Standard: Employed for analytical method development, validation, and quality control of related pharmaceutical products.
• Academic Research: Fundamental research in chemical biology and medicinal chemistry exploring structure-activity relationships (SAR) of epothilone analogs.

Basic Information

Product Name	Sagopilone
CAS No.	305841-29-6
Molecular Formula	C27H41NO5S
Molecular Weight	491.68 g/mol
Synonyms	ZK-EPO; ZK-Epothilone; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; Sagopilone (ZK-EPO); Epothilone B analog ZK-EPO; ZK 219477
EINECS	Contact for details

Quality Control

Our Sagopilone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research-grade materials. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.