Description

3'-o-(2-Methoxyethyl)Adenosine is a chemically modified nucleoside analog, specifically an adenosine derivative with a 2-methoxyethyl group at the 3'-O position. This modification is crucial for enhancing stability and altering the pharmacokinetic profile of oligonucleotide-based therapeutics. It serves as a key building block in the synthesis of antisense oligonucleotides and other advanced pharmaceutical intermediates. This high-purity compound is essential for research and development in the fields of pharmaceutical manufacturing, biotechnology, and life science research.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite monomer for constructing therapeutic oligonucleotides targeting genetic diseases.
• Pharmaceutical Intermediate: Used in the research and development of novel nucleoside-based drugs and prodrugs.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism and processing.
• Molecular Biology: Employed in the development of diagnostic probes and tools for genetic analysis.
• Pre-clinical & Clinical Development: Serves as a key raw material for producing candidate compounds in drug discovery pipelines.
• Contract Manufacturing (CDMO): Supplied to organizations specializing in the custom synthesis of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-o-(2-Methoxyethyl)Adenosine
CAS No.	303197-30-0
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	3'-O-(2-Methoxyethyl)adenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[(2-methoxyethoxy)methyl]oxolan-2-yl]-6-aminopurine; Adenosine, 3'-O-(2-methoxyethyl)-; 2'-O-(2-Methoxyethyl)adenosine (isomeric form); MOE-Adenosine; 3'-MOE-A; 3'-O-Methoxyethyl Adenosine; 3'-O-(2-Methoxyethyl)-adenosine
EINECS	Contact for details

Quality Control

Our 3'-o-(2-Methoxyethyl)Adenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.