Description

3'-O-(2-Methoxyethyl)-5-Methyluridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block in the synthesis of oligonucleotides, particularly for therapeutic applications requiring enhanced stability and pharmacokinetic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other novel nucleic acid-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for constructing oligonucleotides designed to modulate gene expression.
• Small Interfering RNA (siRNA) Development: Used to introduce stabilizing modifications into siRNA strands to improve nuclease resistance and in vivo efficacy.
• Therapeutic Aptamer Production: Employed in the solid-phase synthesis of modified aptamers for targeted drug delivery and diagnostic applications.
• Research on Nucleic Acid Chemistry: Serves as a standard or intermediate in studies exploring the structure-activity relationship of modified nucleosides.
• Prodrug and Conjugate Development: Utilized in creating nucleotide prodrugs or conjugates to enhance cellular uptake and therapeutic index.

Basic Information

Product Name	3'-O-(2-Methoxyethyl)-5-Methyluridine
CAS No.	303197-29-7
Molecular Formula	C13H20N2O7
Molecular Weight	316.31 g/mol
Synonyms	5-Methyl-3'-O-(2-methoxyethyl)uridine; 3'-MOE-5-Methyluridine; 3'-(2-Methoxyethoxy)-5-methyluridine; 5-Methyl-3'-O-(2-methoxyethyl)uridine; Uridine, 5-methyl-3'-O-(2-methoxyethyl)-; 3'-O-Methoxyethyl-5-methyluridine; 5-Me-3'-MOE-U
EINECS	Contact for details

Quality Control

Our 3'-O-(2-Methoxyethyl)-5-Methyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide Certificates of Analysis (COA) with detailed specifications to ensure the material meets the stringent requirements for pharmaceutical research and GMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.