Description

2-Fluoro-5-Trifluoromethylphenyl Isothiocyanate is a high-purity, specialized aromatic isothiocyanate building block essential for advanced organic synthesis. This compound is valued for its reactive isothiocyanate group and the unique electronic properties imparted by its fluorine substituents, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating specialized ligands used in catalysis and material science applications.
• Functional Material Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic backbone and reactive handle.
• Chemical Biology Probe Synthesis: Utilized to create isothiocyanate-functionalized probes for labeling and studying biological molecules and pathways.

Basic Information

Product Name	2-Fluoro-5-Trifluoromethylphenyl Isothiocyanate
CAS No.	302912-40-9
Molecular Formula	C8H3F4NS
Molecular Weight	221.18 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-m-tolyl isothiocyanate; 1-Fluoro-2-isothiocyanato-4-(trifluoromethyl)benzene; 2-Fluoro-5-(trifluoromethyl)phenyl isothiocyanate; 5-Trifluoromethyl-2-fluorophenyl isothiocyanate; Isothiocyanic acid, 2-fluoro-5-(trifluoromethyl)phenyl ester; m-Trifluoromethyl-o-fluorophenyl isothiocyanate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Trifluoromethylphenyl Isothiocyanate is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development projects. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.