Description

3-Azido-n-Boc-D-Alanine Methyl Ester CAS NO 301671-17-0 is a specialized, non-natural amino acid derivative featuring both an azido group and a Boc-protected amine, making it a versatile building block for advanced synthesis. This compound is critical for applications requiring precise molecular assembly, such as click chemistry and peptide modification, due to its orthogonal reactivity. It is primarily utilized by researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics who require high-purity, structurally defined intermediates.

Application

• Peptide Synthesis & Modification: Key intermediate for incorporating azido-functionalized D-alanine residues into peptide chains for subsequent bioorthogonal conjugation.
• Click Chemistry Reagent: Serves as an azide component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages for drug discovery and material science.
• Bioconjugation & Labeling: Used to attach fluorescent dyes, polymers, or other functional moieties to biomolecules like proteins and antibodies.
• Pharmaceutical Intermediate: Building block in the research and development of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Chemical Biology Probes: Enables the study of protein function and interactions through site-specific labeling and activity-based protein profiling.
• Material Science & Polymer Chemistry: Facilitates the synthesis of functionalized polymers and smart materials with tailored properties.

Basic Information

Product Name	3-Azido-n-Boc-D-Alanine Methyl Ester
CAS No.	301671-17-0
Molecular Formula	C9H16N4O4
Molecular Weight	244.25 g/mol
Synonyms	Boc-D-Ala(3-azido)-OMe; (R)-Methyl 3-azido-2-((tert-butoxycarbonyl)amino)propanoate; D-Alanine, 3-azido-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; tert-Butyl (R)-3-azido-1-methoxy-1-oxopropan-2-ylcarbamate; Methyl (2R)-3-azido-2-[(tert-butoxycarbonyl)amino]propanoate; Boc-D-3-azidoalanine methyl ester; Azido-Boc-D-Ala-OMe
EINECS	Contact for details

Quality Control

Our 3-Azido-n-Boc-D-Alanine Methyl Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep container tightly sealed under an inert atmosphere (nitrogen or argon) to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.