Description

2'-Deoxypseudouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of oligonucleotides, enabling the exploration of novel therapeutic modalities. It is primarily utilized by research institutions and biotechnology companies focused on antisense therapy, siRNA development, and diagnostic probe design.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for solid-phase synthesis of modified DNA/RNA strands.
• Antisense & RNAi Therapeutics: Incorporated into oligonucleotides to enhance stability, binding affinity, and pharmacokinetic properties.
• Diagnostic Probe Development: Used in the creation of labeled probes for genetic testing and molecular diagnostics.
• Biochemical Research: A tool compound for studying nucleic acid structure, function, and enzyme interactions.
• Pharmaceutical Intermediate: Serves as a precursor in the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-Deoxypseudouridine
CAS No.	39967-60-7
Molecular Formula	C9H12N2O5
Molecular Weight	228.20 g/mol
Synonyms	2'-Deoxy-ψ-uridine; Pseudodeoxyuridine; 5-(β-D-2'-Deoxyribofuranosyl)uracil; 2'-Deoxy-5-ribosyluracil; d-ψU; 2'-d-ψU; 1-(2-Deoxy-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Our 2'-Deoxypseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are available upon request, ensuring full traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.