Description

Pyridine-2-Carbonyl Chloride Hydrochloride is a versatile and highly reactive chemical building block, primarily used as an acylating agent in organic synthesis. Its value lies in its ability to efficiently introduce the picolinoyl group, a key structural motif in many active pharmaceutical ingredients and advanced materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediates: Key reagent for synthesizing picolinamide-based drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate the pyridine moiety for enhanced activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating complexing agents, chiral ligands, and organometallic catalysts used in asymmetric synthesis.
• Peptide Modification: Employed to acylate amino groups in peptides and proteins for biochemical research and bioconjugation applications.
• Material Science: Building block for synthesizing functional polymers, metal-organic frameworks (MOFs), and other advanced materials with tailored properties.
• Chemical Research & Development: Fundamental reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	Pyridine-2-Carbonyl Chloride Hydrochloride
CAS No.	39901-94-5
Molecular Formula	C7H5Cl2NO
Molecular Weight	190.03 g/mol
Synonyms	Picolinoyl Chloride Hydrochloride; 2-Picolinoyl Chloride Hydrochloride; 2-Pyridinecarbonyl Chloride Hydrochloride; Picolinic Acid Chloride Hydrochloride; α-Pyridinecarbonyl Chloride Hydrochloride; Pyridine-2-carboxylic Acid Chloride Hydrochloride; 2-Carbamoylpyridine Hydrochloride Chloride (obsolete); Picolinoyl Chloride HCl
EINECS	Contact for details

Quality Control

Our Pyridine-2-Carbonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for use in fine chemical and pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.