Description

2-(Biphenyl-4-Yl)Acetyl Chloride is a specialized organic acid chloride derivative of biphenyl, serving as a critical building block in advanced organic synthesis. This compound matters for its high reactivity, enabling the efficient introduction of the 2-(biphenyl-4-yl)acetyl moiety into target molecules. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require the biphenyl scaffold for bioactivity.
• Liquid Crystal & OLED Materials: Serves as a building block for synthesizing advanced organic electronic materials, where the biphenyl group contributes to molecular rigidity and conjugation.
• Polymer Modification: Employed to functionalize polymers and resins, introducing specific side chains to alter material properties like thermal stability or solubility.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Peptide Mimetics & PROTACs: Useful in medicinal chemistry for constructing peptide-like chains or as a linker component in Proteolysis-Targeting Chimeras (PROTACs).
• Chemical Research: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	2-(Biphenyl-4-Yl)Acetyl Chloride
CAS No.	39889-69-5
Molecular Formula	C14H11ClO
Molecular Weight	230.69 g/mol
Synonyms	4-Biphenylacetyl Chloride; 2-(4-Biphenylyl)acetyl Chloride; (1,1'-Biphenyl]-4-acetyl Chloride; 2-(Biphenyl-4-yl)acetyl Chloride; p-Phenylphenylacetyl Chloride; 4-Acetylbiphenyl Chloride; (4-Biphenylyl)acetic Acid Chloride; 2-(4-Phenylphenyl)acetyl Chloride
EINECS	Contact for details

Quality Control

Our 2-(Biphenyl-4-Yl)Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.