Description

19-Hydroxybufalin is a specialized cardiac glycoside derivative, a key intermediate and reference standard in advanced pharmaceutical research and development. Its significance lies in its potent biological activity, which is crucial for studying Na+/K+-ATPase inhibition and related signaling pathways in cardiac and cancer research. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors who require reliable, well-characterized materials for drug discovery, biochemical assays, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in drug manufacturing.
• Biochemical Research: A critical tool for investigating the mechanism of Na+/K+-ATPase inhibition and its downstream effects on cell signaling.
• Drug Discovery & Development: Serves as a key intermediate or active pharmacophore in the synthesis and development of novel therapeutic agents targeting heart failure and certain cancers.
• Academic & Preclinical Studies: Employed in university and institutional labs for in vitro and in vivo studies on cardiotonic activity and apoptosis induction.
• Analytical Chemistry: Used to calibrate instruments and develop HPLC, LC-MS, or other chromatographic methods for the detection of bufalin derivatives.

Basic Information

Product Name	19-Hydroxybufalin
CAS No.	39844-86-5
Molecular Formula	C₂₄H₃₄O₆
Molecular Weight	418.53 g/mol
Synonyms	19-Hydroxybufalin; Bufalin-19-ol; 3β,14-Dihydroxy-19-oxo-5β,14β-bufa-20,22-dienolide; 19-Hydroxy-14,15-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide; 19-Hydroxylbufalin; 19-OH-Bufalin
EINECS	Contact for details

Quality Control

Our 19-Hydroxybufalin is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term storage, consider storing at 2-8°C. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.