Description

2-Butynoyl Chloride is a versatile and highly reactive acid chloride derivative of 2-butynoic acid. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the butynoyl functional group into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring alkyne-functionalized side chains or amide linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate acetylene-based structures for enhanced biological activity.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers, including polyamides and polyesters with unique thermal or mechanical properties.
• Material Science Research: Employed in surface modification, creation of self-assembled monolayers (SAMs), and the development of advanced organic electronic materials.
• Chemical Biology & Proteomics: Useful as a labeling or bioconjugation reagent for modifying peptides, proteins, or other biomolecules via reactions with amines or alcohols.
• Organic Synthesis: A fundamental reagent for Friedel-Crafts acylation, esterification, and amidation reactions to construct complex molecular architectures in academic and industrial R&D.

Basic Information

Product Name	2-Butynoyl Chloride
CAS No.	39753-54-3
Molecular Formula	C4H3ClO
Molecular Weight	102.52 g/mol
Synonyms	But-2-ynoyl chloride; 2-Butynoic acid chloride; Tetrolic acid chloride; 2-Butynoyl chloride; Butynoyl chloride; 1-Propynylcarboxylic acid chloride; 2-Butynoic acid, chloride; 3-Butynoyl chloride (common misnomer)
EINECS	254-634-3

Quality Control

Our 2-Butynoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced analytical techniques including GC, HPLC, and NMR to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.10 - 1.15 g/mL
Refractive Index (n20D)	1.460 - 1.470

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.