Description

(2R)-3β-(Dimethylsilyl)Oxy-2α-[(Dimethylsilyl)Oxy]Methyl-2,3,3Aβ,9Aβ-Tetrahydro-6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-6-One is a sophisticated, high-purity organosilicon-protected nucleoside derivative. This compound is a critical advanced pharmaceutical intermediate (API) used in the synthesis of complex antiviral and anticancer therapeutics. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel nucleoside analogs. The product is supplied with a focus on batch-to-batch consistency and stringent impurity control to ensure reliable downstream processing.

Application

• Key Intermediate in Antiviral Drug Synthesis: Primarily used in the research and production of modified nucleoside analogs targeting viral polymerases.
• Building Block for Anticancer Agents: Serves as a precursor in the development of chemotherapeutic compounds that interfere with DNA/RNA synthesis.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new bioactive molecules in academic and industrial R&D labs.
• Process Chemistry & Scale-Up: Used for optimizing synthetic routes and scaling production from laboratory to pilot and commercial manufacturing scales.
• Silyl Protection in Organic Synthesis: The dimethylsilyloxy groups act as protective groups for hydroxyl functionalities during multi-step synthetic sequences.

Basic Information

Product Name	(2R)-3β-(Dimethylsilyl)Oxy-2α-[(Dimethylsilyl)Oxy]Methyl-2,3,3Aβ,9Aβ-Tetrahydro-6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-6-One
CAS No.	39687-19-9
Molecular Formula	C15H26N2O5Si2
Molecular Weight	370.55 g/mol
Synonyms	2'-Deoxy-2'-C-[(dimethylsilyl)oxy]methyluridine 3',5'-bis(dimethylsilyl) ether; 2'-C-[(Dimethylsilyl)oxy]methyl-2'-deoxyuridine 3',5'-bis-O-(dimethylsilyl) ether; 1-[(2R,4S,5R)-4-[[Dimethyl(trimethylsilyloxy)silyl]oxy]-5-[[dimethyl(trimethylsilyloxy)silyl]oxymethyl]oxolan-2-yl]pyrimidine-2,4-dione; Protected 2'-C- hydroxymethyluridine derivative; Silylated nucleoside intermediate; CAS 39687-19-9.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and impurity profile meet exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing assay, related substances, residual solvents, and other critical parameters is provided with each shipment to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.