Description

(S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride is a high-value chiral derivatizing agent and key synthetic intermediate. Its primary commercial value lies in its role as the chloride precursor to Mosher's acid, a cornerstone reagent for determining the enantiomeric purity and absolute configuration of chiral alcohols and amines via NMR spectroscopy. This compound is essential for research and development laboratories in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical analysis is critical for quality control and regulatory compliance.

Application

• Chiral Derivatization for NMR Analysis: Preparation of Mosher's acid esters and amides to determine enantiomeric excess (ee) and absolute configuration.
• Pharmaceutical Intermediate: Synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective chemical transformations.
• Analytical Reference Standard: Used as a high-purity standard in method development and validation for chiral separations.
• Agrochemical Research: Synthesis of chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Academic & Contract Research: Fundamental tool in university and CRO laboratories for stereochemistry studies and method development.

Basic Information

Item	Details
Product Name	(S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride
CAS No.	39637-99-5
Molecular Formula	C11H8ClF3O2
Molecular Weight	264.63 g/mol
Synonyms	(S)-(+)-MTPA-Cl; (S)-Mosher's Acid Chloride; (S)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride; (S)-MTPA Chloride; (S)-O-Methylmandeloyl Chloride, α-Trifluoromethyl Derivative; (S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl Chloride; (S)-2-Methoxy-2-(trifluoromethyl)-2-phenylethanoyl Chloride
EINECS	Contact for details

Quality Control

Every batch of (S)-(+)-α-Methoxy-α-Trifluoromethylphenylacetyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive chiral analysis and synthesis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is supplied with each shipment, confirming compliance with in-house specifications developed for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, it must be stored in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.