Description

(-)-Camphanic Acid Chloride is a high-purity chiral derivatizing agent and versatile synthetic intermediate essential for stereochemical analysis and asymmetric synthesis. Its primary value lies in its ability to react with racemic alcohols and amines to form diastereomeric derivatives that can be easily separated, enabling the determination of enantiomeric purity. This compound is critically needed by research laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical industries for chiral resolution, the synthesis of enantiomerically pure compounds, and as a key building block in complex organic syntheses.

Application

• Chiral Derivatizing Agent: Used for the resolution of racemic mixtures of alcohols, amines, and amino acids via formation of separable diastereomers for enantiomeric excess (ee) determination.
• Pharmaceutical Intermediate: Serves as a crucial building block in the asymmetric synthesis of active pharmaceutical ingredients (APIs) and other bioactive molecules requiring specific stereochemistry.
• Analytical Chemistry: Employed in High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy to analyze and confirm the stereochemistry of chiral compounds.
• Fine Chemical Synthesis: Acts as a protecting group for alcohols and diols in multi-step synthetic routes due to the stability and bulkiness of the camphor-based moiety.
• Agrochemical Research: Utilized in the development of chiral pesticides and herbicides where biological activity is often stereospecific.
• Academic & Industrial R&D: A fundamental reagent in methodological development for new asymmetric catalytic processes and stereoselective transformations.

Basic Information

Product Name	(-)-Camphanic Acid Chloride
CAS No.	39637-74-6
Molecular Formula	C10H13ClO3
Molecular Weight	216.66 g/mol
Synonyms	(-)-Camphanoyl Chloride; (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl Chloride; L-Camphanic Acid Chloride; (1S)-Camphanic Chloride; 1S-(-)-Camphanic Acid Chloride; (1S,4R)-Camphanic Acid Chloride; NSC 403914
EINECS	Contact for details

Quality Control

Our (-)-Camphanic Acid Chloride is manufactured under strict quality control protocols to ensure high chemical purity and consistent enantiomeric excess, which are critical for reliable analytical and synthetic outcomes. Each batch is analyzed using advanced techniques including Chiral HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing purity, assay, enantiomeric purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Specific Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.