Description

5-Bromonicotinoyl Chloride is a versatile and reactive halogenated nicotinic acid derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 5-bromonicotinoyl moiety into target molecules, enabling the rapid construction of complex heterocyclic scaffolds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to create novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its bromine and carbonyl chloride functionalities.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or photoactive compounds.
• Chemical Biology Probes: Useful for modifying biomolecules or synthesizing activity-based probes for studying enzymatic function.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Bromonicotinoyl Chloride
CAS No.	39620-02-5
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	5-Bromonicotinic Acid Chloride; 5-Bromopyridine-3-carbonyl Chloride; 3-Carbamoyl-5-bromopyridine Hydrochloride (related salt); Nicotinic Acid, 5-Bromo-, Chloride; 5-Bromo-3-pyridinecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 5-Bromonicotinoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, IR and NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.