Description

2-Chlorobenzyl Chloroformate is a versatile and highly reactive acylating agent and protecting group reagent. This compound matters for its critical role in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where it is used to introduce the 2-chlorobenzyloxycarbonyl (2-Cl-Z) protecting group. Industries that need it include pharmaceutical R&D for peptide synthesis, fine chemical manufacturers producing active ingredients, and research institutions developing novel organic compounds.

Application

• As a key reagent for introducing the 2-chlorobenzyloxycarbonyl (2-Cl-Z) protecting group in peptide synthesis.
• As an acylating agent in the production of carbamates and carbonates for pharmaceutical intermediates.
• In the synthesis of agrochemicals, such as herbicides and insecticides, requiring specific chlorobenzyl functionalities.
• For the preparation of specialty polymers and resins where controlled reactivity is essential.
• As a building block in organic chemistry research for constructing complex molecular architectures.
• In the manufacture of dyes and pigments that utilize chlorobenzyl derivatives.

Basic Information

Product Name	2-Chlorobenzyl Chloroformate
CAS No.	39545-31-8
Molecular Formula	C8H6Cl2O2
Molecular Weight	205.04 g/mol
Synonyms	2-Chlorobenzyl Chloroformate; Chloroformic Acid 2-Chlorobenzyl Ester; (2-Chlorophenyl)methyl Carbonochloridate; 2-Chlorobenzyloxycarbonyl Chloride; 2-Cl-Z-Cl; o-Chlorobenzyl Chloroformate; NSC 403079; Carbonochloridic Acid, (2-Chlorophenyl)methyl Ester
EINECS	Contact for details

Quality Control

Our 2-Chlorobenzyl Chloroformate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profile analysis by GC/HPLC, to ensure it meets exacting standards for purity and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density	~1.38 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.