Description

Di-tert-Butylphosphinbromid is a highly reactive organophosphorus bromide compound, primarily utilized as a key ligand precursor in advanced catalytic systems. Its value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and fine chemical synthesis. This chemical is essential for R&D and production chemists in the pharmaceutical, agrochemical, and materials science industries who require sophisticated building blocks for complex molecule construction.

Application

• Precursor for the synthesis of bulky, electron-rich phosphine ligands (e.g., Buchwald-type ligands) for palladium-catalyzed cross-coupling reactions (Suzuki, Negishi, Buchwald-Hartwig amination).
• Intermediate in the development of novel organocatalysts and transition metal complexes for asymmetric synthesis.
• Building block for advanced materials research, including the creation of phosphorus-containing polymers and functional surfaces.
• Key reagent in medicinal chemistry for the late-stage functionalization of complex drug candidates and bioactive molecules.
• Used in academic and industrial R&D laboratories for exploring new catalytic methodologies and reaction pathways.

Basic Information

Product Name	Di-tert-Butylphosphinbromid
CAS No.	39106-95-1
Molecular Formula	C8H18BrP
Molecular Weight	225.11 g/mol
Synonyms	Di-tert-butylphosphinous bromide; (Bromodi-tert-butylphosphine); Di-tert-butylbromophosphine; Di-tert-butylphosphine bromide; t-Bu2PBr; Di-tert-butylphosphane bromide; Di-tert-butylphosphine, bromo-; Di-tert-butylphosphinous acid bromide
EINECS	Contact for details

Quality Control

Our Di-tert-Butylphosphinbromid is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive catalytic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (by NMR), identity confirmation, and moisture content. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Handle and open containers only in a moisture-free environment, such as a glovebox or under a continuous inert gas purge.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (by 31P NMR)	≥ 95%
Moisture (Karl Fischer)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.