Description

3-Oxobutanoyl Chloride is a versatile and highly reactive organic acid chloride derivative of acetoacetic acid. This compound serves as a critical acylating agent and key building block in the synthesis of complex molecules, enabling the introduction of the acetoacetyl functional group. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly β-lactam antibiotics and other heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators requiring acetoacetamide or similar structures.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers, coatings, and adhesives.
• Fine Chemical Production: Essential for manufacturing dyes, pigments, and photographic chemicals.
• Chemical Research & Development: A valuable reagent for organic synthesis, including Friedel-Crafts acylation and the formation of ketones and esters.
• Peptide Modification: Used for the selective acylation of amino groups in peptide chemistry and bioconjugation.

Basic Information

Product Name	3-Oxobutanoyl Chloride
CAS No.	39098-85-6
Molecular Formula	C4H5ClO2
Molecular Weight	120.53 g/mol
Synonyms	Acetoacetyl Chloride; 3-Oxobutyryl Chloride; Acetylacetyl Chloride; 3-Oxobutanoic Acid Chloride; 1-Chloro-2,4-dioxopentane; Butanoyl Chloride, 3-oxo-; β-Ketobutyryl Chloride
EINECS	Contact for details

Quality Control

Our 3-Oxobutanoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous demands of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep away from heat, open flames, and incompatible materials such as strong oxidizers and amines. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acid Chloride Content	≥ 97.0%
Related Impurities (GC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.