Description

14,15β-Epoxy-3β,11α-Dihydroxy-5β-Bufa-20,22-Dienolide is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in synthetic chemistry, pharmacology, and the development of new drug candidates.

Application

• Pharmaceutical Research Intermediate: A key building block in the synthesis of novel bufadienolide analogs for biological evaluation.
• Cardiac Activity Studies: Used as a reference standard or active compound in pharmacological research targeting Na+/K+-ATPase inhibition.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Reagent: Employed in enzymatic and receptor-binding assays to investigate specific biological pathways.
• Reference Standard: Provides a high-purity benchmark for analytical method development and quality control in related compound manufacturing.
• Academic Research: Facilitates studies in natural product chemistry, organic synthesis, and toxicology within university and institutional labs.

Basic Information

Item	Details
Product Name	14,15β-Epoxy-3β,11α-Dihydroxy-5β-Bufa-20,22-Dienolide
CAS No.	39005-15-7
Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51 g/mol
Synonyms	14,15-Epoxy-3,11-dihydroxybufa-20,22-dienolide; 3β,11α-Dihydroxy-14β,15β-epoxy-5β-bufa-20,22-dienolide; Bufadienolide derivative; Resibufogenin epoxy derivative; 14,15-Epoxyresibufogenin; 5β-Bufa-20,22-dienolide, 14,15-epoxy-3β,11α-dihydroxy-; NSC 163049
EINECS	Contact for details

Quality Control

Our 14,15β-Epoxy-3β,11α-Dihydroxy-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide a Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.