Description

2,6-Dichloro-9-(2-Deoxy-3,5,Di-o-(4-Methylbenzoyl-β-D-Erythropentofuranosyl)-9H-Purine) is a sophisticated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. Its complex structure, featuring a purine base with a protected sugar moiety, makes it a critical intermediate for the synthesis of modified oligonucleotides and potential antiviral or anticancer agents. This high-purity compound is essential for research chemists and process development scientists in biotechnology and pharmaceutical companies focused on next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the research and development of modified antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) therapeutics.
• Medicinal Chemistry Research: A vital reagent for structure-activity relationship (SAR) studies to optimize the potency and selectivity of purine-derived compounds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies targeting purine metabolism pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,6-Dichloro-9-(2-Deoxy-3,5,Di-o-(4-Methylbenzoyl-β-D-Erythropentofuranosyl)-9H-Purine)
CAS No.	38925-80-3
Molecular Formula	C31H28Cl2N4O6
Molecular Weight	623.48 g/mol
Synonyms	2',6-Dichloro-2'-deoxy-3',5'-di-O-(4-methylbenzoyl)purine riboside; 2,6-Dichloropurine-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranoside); 9-(2-Deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl)-2,6-dichloro-9H-purine; 2,6-Dichloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)purine; Protected 2,6-Dichloropurine Deoxyriboside; p-Toluoyl Protected 2,6-Dichloro-2'-deoxyadenosine Intermediate
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-9-(2-Deoxy-3,5,Di-o-(4-Methylbenzoyl-β-D-Erythropentofuranosyl)-9H-Purine) is manufactured under strict quality management systems suitable for research and development use. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, NMR, and mass spectrometry are provided to support your critical research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.