Description

4-Chloro-3-Nitrobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, which allow for selective reactions to construct complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzamide or related scaffolds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloronitrobenzoyl moiety is required for bioactivity.
• Dyestuff and Pigment Manufacturing: Serves as an intermediate for creating azo dyes and other complex colorants.
• Polymer Chemistry: Acts as a monomer or modifying agent for engineering plastics and high-performance polymers.
• Liquid Crystal & OLED Materials: A building block for synthesizing advanced electronic and display materials.
• Cross-coupling Reactions: Useful in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination for C-C and C-N bond formation.
• Peptide Mimetics & Bioconjugation: Employed to introduce the chloronitrobenzoyl group into peptides or for protein labeling studies.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways.

Basic Information

Product Name	4-Chloro-3-Nitrobenzoyl Chloride
CAS No.	38818-50-7
Molecular Formula	C7H3Cl2NO3
Molecular Weight	220.01 g/mol
Synonyms	3-Nitro-4-chlorobenzoyl chloride; 4-Chloro-3-nitrobenzoic acid chloride; Benzoic acid, 4-chloro-3-nitro-, chloride; 4-Chloro-3-nitro-benzoylchlorid; NSC 403121; 1-Chloro-4-(chlorocarbonyl)-2-nitrobenzene; 2-Nitro-4-chlorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Nitrobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.