Description

1,N(6)-Ethenoadenosine 3',5'-Monophosphate is a chemically modified cyclic nucleotide derivative, specifically an etheno-bridged analog of adenosine 3',5'-cyclic monophosphate (cAMP). This compound is of significant value as a stable, fluorescent probe in biochemical and pharmacological research, offering enhanced resistance to enzymatic degradation compared to its native counterpart. It is primarily needed by researchers and manufacturers in the life sciences sector for studying cyclic nucleotide-dependent signaling pathways, enzyme kinetics, and as a tool in high-throughput screening assays.

Application

• Biochemical Research: Used as a stable, fluorescent analog of cAMP to investigate the structure, function, and dynamics of protein kinases (PKA), phosphodiesterases, and other cAMP-binding proteins.
• Enzyme Assay Development: Serves as a substrate or inhibitor in enzymatic activity assays, particularly for phosphodiesterases, due to its altered hydrolysis profile.
• Cell Signaling Studies: Employed as a cell-permeable tool compound to modulate or monitor intracellular cAMP levels and related second messenger pathways.
• Diagnostic Kit Manufacturing: Can be incorporated as a key component in diagnostic kits and reagents for research use only (RUO) to detect or quantify enzyme activity.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and other receptors linked to adenylate cyclase activity.
• Fluorescence Spectroscopy: Acts as an intrinsic fluorescent probe for biophysical studies, including protein-ligand binding interactions and conformational changes.

Basic Information

Product Name	1,N(6)-Ethenoadenosine 3',5'-Monophosphate
CAS No.	38806-37-0
Molecular Formula	C12H13N5O6P
Molecular Weight	378.24 g/mol
Synonyms	1,N6-Etheno-cAMP; ε-cAMP; 1,N6-Ethenoadenosine cyclic 3',5'-(hydrogen phosphate); Etheno-cyclic AMP; Fluorescent cAMP analog; 1,N6-Etheno-3',5'-cyclic adenosine monophosphate; 3',5'-Cyclic AMP 1,N6-etheno derivative
EINECS	Contact for details

Quality Control

Our 1,N(6)-Ethenoadenosine 3',5'-Monophosphate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.