Description

5-Hydroperoxymethyl-2'-Deoxyuridine is a chemically modified nucleoside derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical intermediate and a model substrate for studying oxidative DNA damage and repair mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and advanced diagnostic tools.

Application

• Biochemical Research: As a key substrate for investigating the mechanisms and kinetics of oxidative damage to DNA nucleosides.
• Pharmaceutical Development: Used as a synthetic intermediate in the research and development of nucleoside-based antiviral or anticancer prodrugs.
• Analytical Reference Standard: Serves as a high-purity standard for analytical methods (e.g., HPLC, LC-MS) to quantify oxidative DNA lesions in biological samples.
• Enzymology Studies: Employed in studies to characterize the activity and specificity of DNA repair enzymes, such as glycosylases.
• Radiobiology & Toxicology: Used in research exploring the biological effects of ionizing radiation and reactive oxygen species (ROS) on genetic material.

Basic Information

Product Name	5-Hydroperoxymethyl-2'-Deoxyuridine
CAS No.	38716-10-8
Molecular Formula	C10H14N2O7
Molecular Weight	274.23 g/mol
Synonyms	5-(Hydroperoxymethyl)-2'-deoxyuridine; 5-HPMdU; 2'-Deoxy-5-(hydroperoxymethyl)uridine; 5-(Hydroperoxymethyl)deoxyuridine; dU-5-CH2OOH; 5-Hydroperoxymethyldeoxyuridine
EINECS	Contact for details

Quality Control

Our 5-Hydroperoxymethyl-2'-Deoxyuridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research applications. A detailed Certificate of Analysis (COA) documenting purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize decomposition due to its easily oxidized and light-sensitive nature. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.