Description

Filipin Ii CAS NO 38620-77-8 is a polyene macrolide antibiotic complex, primarily known for its potent antifungal properties and its specific interaction with membrane sterols. This compound matters for its critical role as a biochemical tool in research, particularly for studying cholesterol distribution and membrane structure in eukaryotic cells. It is needed by researchers in biochemistry, cell biology, and pharmacology, as well as by manufacturers developing diagnostic assays and antifungal formulations.

Application

• Biochemical Research: A vital tool for the selective detection and visualization of membrane cholesterol in cellular and model membrane systems.
• Antifungal Studies: Used in research to investigate mechanisms of antifungal action and to screen for synergistic compounds.
• Cell Biology: Employed to study lipid raft dynamics, membrane fluidity, and sterol-dependent signaling pathways.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the development of novel antifungal agents.
• Diagnostic Reagents: Incorporated into kits and stains for the histochemical detection of free cholesterol in tissues.
• Microbiology: Used in laboratory settings to study the susceptibility of various fungal strains.

Basic Information

Product Name	Filipin Ii
CAS No.	38620-77-8
Molecular Formula	C35H58O11
Molecular Weight	654.83 g/mol
Synonyms	Filipin II; Filipin Complex; Filipin III (common component reference); NSC 232444; U 5956; Antibiotic U 5956; Polyene Antibiotic Filipin; 5,7,9,11,13,15,17,19,21,23,25,27,29-Tridecahentriaconta-2,4,6,8,10,12,14,16,18,20,22,24,26,28-tetradecaene-1,30-diol, 3,29-dihydroxy-30-methyl-
EINECS	Contact for details

Quality Control

Our Filipin Ii is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere such as argon or nitrogen, due to its light-sensitive and easily oxidized nature. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95% (Filipin II)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.