Description

S(+)-N6-(2-Phenylisopropyl)Adenosine (S(+)-PIA) is a highly selective and potent agonist for the adenosine A1 receptor. This compound is a critical research-grade biochemical tool used extensively in pharmacological and neurological studies to investigate adenosine signaling pathways. It is essential for researchers and pharmaceutical developers in the fields of neuroscience, cardiology, and metabolic disease research who require high-purity, well-characterized ligands for receptor binding assays and in vitro studies.

Application

• Pharmacological Research: A key tool for studying adenosine A1 receptor function, activation, and downstream signaling cascades in cellular and tissue models.
• Neuroscience Studies: Used to investigate the role of adenosine receptors in neurotransmission, neuroprotection, and conditions like sleep regulation, epilepsy, and pain perception.
• Cardiovascular Research: Employed in studies exploring the cardioprotective effects, heart rate modulation, and ischemic preconditioning mediated by A1 receptor activation.
• Metabolic Disorder Research: Applied in research on insulin sensitivity, lipolysis, and other metabolic processes influenced by adenosine signaling.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in the synthesis of related compounds.
• Drug Discovery & Development: A vital compound for high-throughput screening (HTS), lead optimization, and preclinical evaluation of new therapeutic agents targeting the adenosine system.

Basic Information

Product Name	S(+)-N6-(2-Phenylisopropyl)Adenosine (S(+)-PIA)
CAS No.	38594-97-7
Molecular Formula	C19H23N5O4
Molecular Weight	385.42 g/mol
Synonyms	S(+)-PIA; (2S)-N6-(2-Phenylethyl)adenosine; (S)-(-)-N6-(2-Phenyl-1-methylethyl)adenosine; (S)-N6-(2-Phenylisopropyl)adenosine; S-(-)-N6-(2-Phenylisopropyl)adenosine; Adenosine, N6-[(1S)-2-phenyl-1-methylethyl]-; N6-[(1S)-2-Phenyl-1-methylethyl]adenosine; A1 adenosine receptor agonist (S(+)-isomer)
EINECS	Contact for details

Quality Control

Our S(+)-N6-(2-Phenylisopropyl)Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee reliable and reproducible performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.