Description

(-)-N6-(2-Phenylisopropyl)-Adenosine is a potent and selective adenosine A1 receptor agonist, a key compound in biochemical and pharmacological research. Its high specificity makes it an invaluable tool for studying adenosine receptor signaling pathways and their physiological effects. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for investigating cardiovascular, neurological, and metabolic disorders.

Application

• Pharmacological Research: A standard reference agonist for studying adenosine A1 receptor function, signaling, and desensitization.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel A1 receptor modulators or antagonists.
• Neuroscience Studies: Investigation of neuroprotective mechanisms, synaptic transmission, and the role of adenosine in sleep regulation, pain perception, and epilepsy.
• Cardiovascular Research: Exploration of cardioprotective effects, including heart rate reduction, anti-ischemic properties, and preconditioning mechanisms.
• Metabolic Disorder Research: Study of insulin sensitivity, lipolysis, and other metabolic processes influenced by adenosine A1 receptor activity.
• Biochemical Assay Standard: Serves as a critical standard for calibrating bioassays and ensuring experimental reproducibility in receptor binding studies.

Basic Information

Product Name	(-)-N6-(2-Phenylisopropyl)-Adenosine
CAS No.	38594-96-6
Molecular Formula	C19H23N5O4
Molecular Weight	385.42 g/mol
Synonyms	(-)-PIA; R(-)-N6-(2-Phenylisopropyl)adenosine; (R)-(-)-N6-(1-Methyl-2-phenylethyl)adenosine; R-PIA; N6-(1-Methyl-2-phenylethyl)adenosine; Adenosine, N6-(1-methyl-2-phenylethyl)-, (R)-; CV 1808; A1 Adenosine Receptor Agonist
EINECS	Contact for details

Quality Control

Our (-)-N6-(2-Phenylisopropyl)-Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.