Description

Guanosine 2',3'-Cyclophosphorothioate is a chemically modified nucleoside analog featuring a sulfur-substituted cyclic phosphate group. This structural modification is critical for its role as a key intermediate and research tool in the development of nucleotide-based therapeutics and diagnostics. It is primarily utilized by research institutions and pharmaceutical companies engaged in oligonucleotide synthesis, antisense technology, and RNA biochemistry. The compound's unique phosphorothioate linkage offers enhanced nuclease resistance, making it valuable for probing biological mechanisms and creating novel bioactive molecules.

Application

• Oligonucleotide Synthesis: Serves as a vital building block (phosphoramidite precursor) for the solid-phase synthesis of antisense oligonucleotides and siRNA with phosphorothioate backbones.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of ribonucleases, polymerases, and other nucleic acid-processing enzymes.
• Pharmaceutical Development: An important intermediate in the research and development of nucleotide-based drugs targeting viral infections, genetic disorders, and cancers.
• Diagnostic Probe Development: Employed in the creation of labeled probes and primers for advanced molecular diagnostics and detection assays.
• Structural Biology Studies: Utilized to incorporate stable, hydrolysis-resistant linkages into RNA analogs for X-ray crystallography and NMR spectroscopy studies.

Basic Information

Product Name	Guanosine 2',3'-Cyclophosphorothioate
CAS No.	38557-85-6
Molecular Formula	C10H12N5O6PS
Molecular Weight	361.27 g/mol
Synonyms	2',3'-Cyclic Phosphorothioate Guanosine; Guanosine 2',3'-Cyclic Phosphorothioate; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one 2,3-cyclic phosphorothioate; G-2',3'-cPS; 2',3'-cGMPS; Guanosine 2',3'-cyclic monophosphorothioate
EINECS	Contact for details

Quality Control

Our Guanosine 2',3'-Cyclophosphorothioate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to a rigorous quality management system to support our commitment to reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.