Description

Cyclobutanecarbonyl Chloride, 3-Chloro-, cis- (9Ci) is a specialized, high-purity chemical building block characterized by its reactive acid chloride functional group and a cis-configured chlorinated cyclobutane ring. This compound matters as a critical chiral intermediate for the synthesis of complex, biologically active molecules, enabling precise stereochemical control in advanced pharmaceutical development. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, constrained ring systems.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides, where the cyclobutane scaffold can contribute to unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel monomers or polymers with specific structural properties derived from the strained cyclobutane ring.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 3-Chloro-, cis- (9Ci)
CAS No.	38353-16-1
Molecular Formula	C5H6Cl2O
Molecular Weight	153.01 g/mol
Synonyms	cis-3-Chlorocyclobutanecarbonyl chloride; (1s,3s)-3-Chlorocyclobutanecarbonyl chloride; 3-Chlorocyclobutanecarboxylic acid chloride, cis-; Cyclobutanecarbonyl chloride, 3-chloro-, (cis)-; 38353-16-1; cis-3-Chlorocyclobutane-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 3-Chloro-, cis- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with water and alcohols; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.