Description

Cyclobutanecarbonyl Chloride, 3-Chloro-, trans- (9Ci) is a specialized organic acid chloride derivative of cyclobutane, serving as a high-value chiral building block in advanced synthesis. This compound matters for its ability to introduce the constrained cyclobutane ring and an acid chloride functional group, enabling efficient amide and ester bond formation under mild conditions. It is primarily needed by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients, as well as by academic and industrial researchers in material science exploring new polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, particularly in protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Monomer or precursor for synthesizing specialty polymers and liquid crystalline materials with unique thermal and mechanical properties.
• Peptide Mimetics: Used to incorporate rigid, non-natural amino acid analogs into peptide chains to enhance metabolic stability and binding affinity.
• Chemical Biology Probes: Serves as a reactive handle for labeling or modifying biomolecules to study protein function and interactions.
• Catalyst Ligand Development: Precursor for synthesizing novel chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 3-Chloro-, trans- (9Ci)
CAS No.	38352-91-9
Molecular Formula	C5H6Cl2O
Molecular Weight	153.01 g/mol
Synonyms	trans-3-Chlorocyclobutanecarbonyl chloride; (1r,3r)-3-Chlorocyclobutanecarbonyl chloride; (trans)-3-Chlorocyclobutanecarboxylic acid chloride; 3-Chlorocyclobutanecarbonyl chloride, trans-; Cyclobutanecarbonyl chloride, 3-chloro-, trans-; 38352-91-9; trans-3-Chlorocyclobutanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 3-Chloro-, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and GC, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed and allowed to reach ambient temperature before opening to prevent condensation and hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% trans-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.