Description

3',5'-Anhydrothymidine is a specialized nucleoside analog and a key synthetic intermediate in organic chemistry. This compound is valued for its role in the synthesis of modified nucleosides and nucleotides, which are crucial for pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, nucleic acid chemistry, and the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies exploring enzyme mechanisms, DNA/RNA synthesis inhibition, and structure-activity relationships (SAR).
• Prodrug Development: Serves as a precursor in the design of prodrugs to enhance bioavailability and targeting of active pharmaceutical ingredients (APIs).
• Antiviral Agent Synthesis: Integral to the research and development pipeline for compounds targeting viruses such as HIV, hepatitis, and herpes.
• Labeled Compound Production: A starting material for the synthesis of isotopically labeled (e.g., C13, N15) compounds for metabolic and pharmacokinetic studies.
• Academic & Industrial R&D: Employed in university laboratories and corporate R&D centers for exploratory chemistry and new molecular entity development.

Basic Information

Product Name	3',5'-Anhydrothymidine
CAS No.	38313-48-3
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; Thymidine, 2',3'-anhydro-; 2',3'-Anhydrothymidine; 3',5'-Anhydro-2'-deoxythymidine; NSC 143491; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 3',5'-anhydro derivative
EINECS	Contact for details

Quality Control

Our 3',5'-Anhydrothymidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.