Description

2-Trimethylsilyloxysuccinic Acid Di(Trimethylsilyl) Ester is a highly functionalized organosilicon compound, primarily valued as a versatile silylating agent and protected intermediate in advanced organic synthesis. Its core value proposition lies in enabling complex synthetic routes, particularly for sensitive or multifunctional molecules, by providing robust protection for carboxylic acid and hydroxyl groups under anhydrous conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of active ingredients and complex organic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring protection of carboxylic acid functionalities during multi-step reactions.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific functional group manipulation is necessary.
• Peptide Chemistry: Serves as a protecting group reagent for aspartic and glutamic acid side chains during solid-phase peptide synthesis (SPPS).
• Natural Product Synthesis: Facilitates the synthesis of complex natural products by protecting sensitive diacid or hydroxyl-acid motifs.
• Polymer & Material Science: Acts as a monomer or modifying agent in the synthesis of specialized silicon-containing polymers and advanced materials.
• Analytical Derivatization: Employed to derivative polar organic acids for Gas Chromatography (GC) or GC-Mass Spectrometry (GC-MS) analysis, improving volatility and detection.

Basic Information

Product Name	2-Trimethylsilyloxysuccinic Acid Di(Trimethylsilyl) Ester
CAS No.	38166-11-9
Molecular Formula	C13H30O5Si3
Molecular Weight	350.63 g/mol
Synonyms	Succinic Acid, 2-(Trimethylsiloxy)-, Bis(trimethylsilyl) Ester; 2-(Trimethylsiloxy)succinic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) 2-(trimethylsiloxy)succinate; 2-(Trimethylsilyloxy)butanedioic Acid Di(trimethylsilyl) Ester; TMS-protected Succinic Acid Derivative; 38166-11-9; Tris(trimethylsilyl) O-succinate
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilyloxysuccinic Acid Di(Trimethylsilyl) Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including GC, HPLC, and NMR analysis, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.