Description

Iodoacetyl Chloride is a highly reactive bifunctional reagent featuring both an acid chloride and an iodoacetyl group. This compound is essential for introducing sulfhydryl-reactive iodoacetyl groups into target molecules under mild conditions, enabling precise bioconjugation and cross-linking. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing antibody-drug conjugates (ADCs), peptide modifications, and site-specific protein labeling.

Application

• Bioconjugation Reagent: Primary reagent for the site-specific modification of proteins, peptides, and antibodies via cysteine residues.
• Antibody-Drug Conjugate (ADC) Synthesis: Key building block for creating stable thioether linkages between cytotoxic payloads and monoclonal antibodies.
• Cross-linking Agent: Used to create covalent bridges between biomolecules for studying protein-protein interactions or stabilizing complexes.
• Peptide Synthesis: Employed as an iodoacetylating agent for the side-chain functionalization of peptides during solid-phase or solution-phase synthesis.
• Proteomics Research: Tool for affinity labeling, activity-based protein profiling (ABPP), and the introduction of tags or probes onto thiol-containing enzymes.
• Polymer Functionalization: Modifies polymers and surfaces with iodoacetyl groups to create reactive platforms for further biomolecule immobilization.

Basic Information

Product Name	Iodoacetyl Chloride
CAS No.	38020-81-4
Molecular Formula	C2H2ClIO
Molecular Weight	204.40 g/mol
Synonyms	2-Iodoacetyl Chloride; Chloro(iodo)acetyl; Iodoacetic Acid Chloride; Iodoacetyl Chloride; α-Iodoacetyl Chloride; (Iodoacetyl) chloride; Acetyl chloride, 2-iodo-; NSC 401122
EINECS	253-746-5

Quality Control

Our Iodoacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, appearance, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere. Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as bases, amines, and oxidizing agents. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (by GC)	≥ 90.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.