Description

(4S,5R,6R)-5-Acetamido-6-[(1S,2R)-1,2-Dihydroxy-3-Phosphonooxy-Propyl]-2,4-Dihydroxy-Oxane-2-Carboxylic Acid is a high-purity, stereochemically defined intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters as a key chiral building block for the development of novel therapeutics, particularly in the field of antiviral and antibacterial agents. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers requiring precise stereochemistry and high-quality intermediates for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of complex nucleoside analogs and other bioactive molecules.
• Antiviral Drug Research: Used in the development and production of experimental antiviral compounds targeting specific enzymatic pathways.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving kinases and transferases.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: A starting point for the custom synthesis of specialized derivatives for proprietary drug discovery programs.

Basic Information

Product Name	(4S,5R,6R)-5-Acetamido-6-[(1S,2R)-1,2-Dihydroxy-3-Phosphonooxy-Propyl]-2,4-Dihydroxy-Oxane-2-Carboxylic Acid
CAS No.	37992-17-9
Molecular Formula	C11H20NO12P
Molecular Weight	365.25 g/mol
Synonyms	5-Acetamido-6-(1,2-dihydroxy-3-phosphonooxypropyl)-2,4-dihydroxyoxane-2-carboxylic acid; Oseltamivir phosphate intermediate; Oseltamivir impurity standard; GS 4071 intermediate; Phosphonooxyethyl Derivative of Zanamivir precursor; (3R,4R,5S)-5-Acetamido-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic Acid phosphate related compound; 2,4-Dideoxy-2,4-diamino-5-N-acetyl-3-O-(dipropyl)-D-glycero-D-galacto-non-2-enopyranosonic acid phosphate analog.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP guidelines for pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Optical Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.