Description

5-Methoxy-4-Thiouridine is a chemically modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a versatile molecular probe for studying RNA structure, function, and metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, antiviral drug discovery, and the development of novel therapeutic agents. The high-purity material is essential for ensuring reproducible and reliable experimental outcomes in these demanding applications.

Application

• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies related to RNA synthesis and modification.
• Antiviral Drug Discovery: Serves as a key intermediate or analog in the synthesis of potential nucleoside-based antiviral compounds.
• RNA Structure Probing: Acts as a site-specific label or probe to investigate RNA folding, dynamics, and protein-RNA interactions.
• Medicinal Chemistry: Employed as a building block for the design and synthesis of novel therapeutic candidates targeting various diseases.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and nucleic acid chemistry.
• Process Development: Used in scaling up synthetic routes for the production of related nucleoside derivatives.

Basic Information

Product Name	5-Methoxy-4-Thiouridine
CAS No.	37805-89-3
Molecular Formula	C10H14N2O6S
Molecular Weight	290.29 g/mol
Synonyms	4-Thio-5-methoxyuridine; 5-Methoxy-4-thiouridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-4-thioxo-1,2,3,4-tetrahydropyrimidin-2-one; 4-Thiouridine, 5-methoxy-; 5-Methoxy-4-thio-uridine; 4-Thio-5-O-methyluridine
EINECS	Contact for details

Quality Control

Our 5-Methoxy-4-Thiouridine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your technical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.