Description

3'-Deoxy-3'--C-Methyl-5-Fluorouridine is a chemically modified nucleoside analog, representing a key intermediate in the synthesis of advanced pharmaceutical compounds. Its value lies in its structural role as a building block for novel antiviral and anticancer agents, enabling targeted therapeutic development. This high-purity intermediate is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a building block for creating chemotherapeutic agents that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Employed in studies of nucleoside metabolism, enzyme inhibition, and structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Utilized in the optimization and commercial-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	3'-Deoxy-3'--C-Methyl-5-Fluorouridine
CAS No.	37731-67-2
Molecular Formula	C11H15FN2O5
Molecular Weight	274.25 g/mol
Synonyms	3'-Deoxy-3'-C-methyl-5-fluorouridine; 3'-Deoxy-3'-methyl-5-fluorouridine; 5-Fluoro-3'-deoxy-3'-C-methyluridine; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 3'-Deoxy-3'-methyl-5-fluoro-uridine; 5-Fluoro-3'-deoxy-3'-methyluridine
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'--C-Methyl-5-Fluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.